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The catalytic domain of CES1 encompasses a serine hydrolase catalytic triad that is located at the bottom of a deep active site cleft (Fig. 2).
South-facing slopes are characterized by a deep active layer and warm and well-drained soils with probable drought stress in mid-summer; the ALT depends on the year, but is generally approximately 120 cm for south-facing slopes.
Limiting the study to these models was due to the following reasons: (1) some climate models do not provide soil temperature data; (2) models with a horizontal resolution larger than 2.5° were not selected for this small-area study; and (3) models with a soil depth shallower than 6 m were eliminated due to the presence of a deep, active soil layer in the study region.
Each monomer (Figure 4A) consists of two major domains separated by a deep active site cleft and contains six subdomains involved in the ATPase core (light green), intersubunit interactions (aquamarine) and substrate binding (red).
Thus, a deep active site crevice, two active site ions, and conserved P-loop residues stabilizing the γ-phosphate of RNA are defining features of atypical DSPs that specialize in dephosphorylating 5′-RNA.
Similar(55)
The enzyme has the common eight-fold TIM-barrel structure of family 10 xylanases; however, unlike non-alkaline active xylanases, it has a highly negatively charged surface and a deeper active site cleft.
For both enzymes, hydrolysis takes place near the bottom of a 20 Å deep active site gorge.
Furthermore, the architecture of the cap domain results in an unusually deep active-site pocket with topological features to restrict binding to small or kinked substrates.
They have a deep and active commitment to public benefit".
Yet FPK is "in no doubt that a deep and active market in insurance-risk securities will ultimately develop".
We synthesized a fluorogenic dansylamide derivative (JB2-48), which fills the entire (15 Å deep) active site pocket of human carbonic anhydrase I, and investigated the contributions of sulfonamide and hydrophobic regions of the ligand structure on the spectral, kinetic, and thermodynamic properties of the enzyme ligand complex.
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