These results demonstrate that a dedicated regulation of key pluripotency regulators, such as c-Myc, by NMD is a novel mechanism to orchestrate the network of self-renewal and differentiation of ESCs and also in iPSC production.
We can presume that PhoP is a global regulator that controls a complex regulatory cascade by a mechanism of not only directly controlling the expression of specific genes, but also indirectly regulating various cellular pathways by acting on a set of dedicated regulators.
In the bacterium Escherichia coli the transcriptional regulation of gene expression involves both dedicated regulators binding specific DNA sites with high affinity and also global regulators – abundant DNA architectural proteins of the bacterial nucleoid binding multiple sites with a wide range of affinities and thus modulating the superhelical density of DNA.
These results add to the mounting evidence that Lrig proteins are not dedicated regulators of ErbB signaling; rather, they may have multiple functions.
Supporting the existence of a Deinococcus radiation response regulon, a common palindromic DNA motif was identified in a conserved set of genes associated with resistance, and a dedicated transcriptional regulator was predicted.
When a certain density or "quorum" of extracellular autoinducer molecules is reached, the autoinducer binds to a dedicated transcriptional regulator, thereby activating transcription of specific genes.
Validating these putative regulators required a dedicated functional genomics approach, which was the goal of the present study.
Basonuclin's high affinity binding site overlaps with the binding site of a dedicated and ubiquitous Pol I transcription regulator, UBF, suggesting that their binding might interfere with each other if they bind to the same promoter.
Deubiquitinases (DUBs) are key regulators of Ub signaling, but a dedicated DUB for Met1 linkages has not been identified.
The move to launch a dedicated privacy and security site is in direct response to these regulators' concerns.
