Decreased gluconeogenic activity may indicate a decreased requirement for new amino sugars for cell wall synthesis, and this observation corresponded with the decreased expression of genes involved with cell wall synthesis and cell division.
In the propofol-ketamine group, there was a decreased requirement for inotropic agents after CPB (22% of patients) compared with controls (49% of patients; p = 0.02).
In this case, both the auditory and visual surrounds are largely invariant due to the early maturation of the eye and ear sensory elements during juvenile stages, hence reflecting a decreased requirement for transcriptional competence.
This accumulation in the late stages of development is probably the result of a decreased requirement for hypoxanthine by the parasite after the DNA of daughter merozoites has been synthesized.
In addition, a large number of genes involved in protein degradation (97 genes in total) were down-regulated, indicating a decreased requirement for proteolytic activity.
A decreased requirement for Rad52 activity during Rad51 focus formation in the srs2Δ mutant was observed, suggesting that Srs2 antagonizes Rad52 in the formation of Rad51 filaments [60].
Previous studies have also suggested that chloride-restrictive fluid administration and a limited use of HES were associated with a decreased requirement for RRT and mortality [ 11, 16, 17, 22, 39].
The presence of DBC1 in fish may have resulted in a decreased requirement for the LZ domain in CCAR1, ultimately affecting the current functional role of the LZ in modern DBC1 and CCAR1.
Even at the highest concentrations of the small molecule the mINR and mIGFR UTRs remain roughly 50% active indicating a decreased requirement for eIF4A relative to the control RNA.
This discrepancy may be a mouse-specific phenomenon resulting from a decreased requirement for 'second hits' at Fbxw7 compared with humans, 38 as our in vitro data suggest; or it may reflect the fact that heterozygous null human FBXW7 genotypes do have some, submaximal, tumour promoting effects, perhaps in a continuum fashion.
