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However, at higher filler contents a decreased propensity for crystallization was noted, which again indicated network formation.
The C48A and C139A mutants of hPNMT, which are incapable of forming the disulfide bond observed in the crystal structure, have a decreased propensity to form dimer in solution.
The regioisomeric 2- and 3-ketopyrrolidines demonstrated high levels of potency against all three monoamine transporters as well as good human in vitro stability, low drug drug interaction potential and a decreased propensity for hERG channel binding.
Its advantages are single site cannulation and a decreased propensity for recirculation [ 31].
iPSCs derived from mouse neural progenitors, for example, contained methylomic signatures at loci important for hematopoietic differentiation, resulting in a decreased propensity for differentiating into hematopoietic cell types.
Interestingly, the antimony-resistant phenotype of field isolates was reported to be accompanied by a decreased propensity to undergo apoptosis following exposure to either SbIII, MF or AMB.
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Accordingly, the behavior of the Gln1 mutants could also be explained by an increased or decreased propensity to undergo structural changes.
To explain this apparent contradiction, increased uptake or decreased propensity to form structures have been suggested as possible mechanisms.
These chelating ligands are based on the 1,4,7-triazacyclononane (TACN) structure and have been chosen to allow enhanced efficiency in protein capture and decreased propensity for metal ion leakage in the immobilized metal ion affinity chromatographic (IMAC) purification of recombinant proteins.
For vascular imaging, SNR and CNR may be improved by nanoparticles contrast agents with (1) decreased propensity for indiscriminate extravasation, thus, reducing vessel blurring; and, (2) long intravascular circulation time, thus, reducing the need for bolus tracking.
Phosphine coordinated Pt-dications emerged as superior catalysts, partially due to their stronger metal ligand bonds, their decreased propensity to cause problematic alkene isomerizations, and their ability to initiate catalytic, ligand-controlled cation olefin cyclizations.
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