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An 18-fold increase in weight was observed in subcutaneous inguinal fat pads of Leptin145E/145E mice.
No noticeable decrease in weight is observed in the argon atmosphere sample until approximately 650°C.
Further, no significant decreases in body weight were observed in mice in any of the six treatment groups.
A 7.5 % decrease in weight was observed from baseline to week 24 (P < 0.0001).
A significant decrease in body weight was observed in male Tg mice, whereas the average weight of female Tg mice was not reduced significantly compared with WT controls.
No change in the body weight was observed in these mice (Fig. 5A).
In addition, significant loss of body weight was observed in 3 weeks in MCD diet-fed mice.
Maximal body weight decrease reaching 5% was observed in mice treated with capecitabine alone or combined with PRI-2191 (data not shown).
No pronounced tissue damage or toxicities such as diarrhoea or a decrease in body weight of >10% were observed in mice in any of the four treatment groups.
Decreases in body weight were observed in all groups.
Small decreases in mean body weight were observed in all treatment groups.
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