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They suggest that alterations in transmitter release likely underlie age-related cognitive and behavioral decline, which is definitely implied by the experiments they performed, but they did not actually establish that there was a decrease in transmitter release.
Activation of presynaptic Kv7 channels leads to a decrease in transmitter release from cerebrocortical nerve terminals, while inhibition causes the opposite effect (Luisi et al., 2009), and the same holds true for SCG neurons (Hernandez et al., 2008).
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These results therefore suggest that prolonged UCB exposure not only causes a decrease in presynaptic transmitter release but also impairs the postsynaptic NMDA receptor function.
15 A decrease in excitatory transmitter release results in decreased α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and glutamate receptor activation, and a decrease in pain transmission signaling.
Observed presynaptic changes due to exposure to H2O2 were a decrease in the amount of transmitter released, that is, quantal content, as well as a decrease in the fast facilitation, that is, the amplitude increase of successive excitatory junction potentials at a rate of 3 Hz.
The affinity constants suggest a decrease in release of these transmitters as well.
With the increased number of transmitters, a decrease in the maximum RMSDS value and an increase in the minimum of RMSDS occur, since the strong light components are distributed more widely.
Both mutants showed a decrease in eEPSC amplitude, but although this was attributable to defective transmitter release at UNC-51 mutant synapses, no such presynaptic defect was observed in RSK mutants (unchanged quantal content; Fig. 6C).
Loss of UNC-51, a negative regulator of ERK, leads to a decrease in the number and density of synapses, apposition defects of GluR fields with presynaptic active zones and impairment of evoked transmitter release (Wairkar et al., 2009).
"Ivan took a decrease in compensation last year.
A decrease in height.
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