The phrase "a decrease in spine" is not correct and may be confusing in written English.
It could be used in a context discussing a reduction in the physical structure or metaphorical strength of a spine, but it lacks clarity.
Example: "The recent studies indicate a decrease in spine density among older adults, which may lead to increased risk of fractures."
Alternatives: "a reduction in spine" or "a decline in spine".
Stressed mother rats exhibit depressive-like behavior in the forced swim test, less maternal care, and a decrease in spine density in the medial prefrontal cortex (Leuner et al. 2014).
In addition to the shortened primary dendrite length, however, the KI mice also showed a decrease in spine number.
In contrast, only in neocortical pyramidal neurons has a decrease in spine density been demonstrated in mice carrying human APP bearing the Swedish mutation [36].
Compared with vector-transfected cells, neurons overexpressing wildtype TRIM3 showed a decrease in spine head width, while those overexpressing the putative dominant negative TRIM3 mutants had enlarged spine heads (Figure 5A, B) There was little effect on spine length (Figure S3A) or spine density (spines/10 µm ± SEM; Control: 4.79±0.18; TRIM3 4.88±0.22; ΔRING 5.36±0.29; C22S/C25.36±0.29.21).
Close to plaques (<30 µm) a decrease in spine density and increase in the fraction of stubby spines were observed.
Medium-spiny neurons in the NAcbC are particularly sensitive to a decrease in spine density in the absence of DA (69).
The aged brain exhibits a loss in gray matter and a decrease in spines and synaptic densities that may represent a sequela for neurodegenerative diseases such as Alzheimer's.
While increase in the number of spines were reported on CA3 pyramidal dendrites and in the size of the post-synaptic densities on CA1 synapses, others could not find changes in spine density [ 129] or reported a decrease in spines, that was notably rapidly reversible already after a recovery period or subsequent training [ 1, 176, 205].
This shift may be due to a decrease in the spine size of 'mushroom-like' synapses, thereby increasing the number of 'thin' spines.
Thus, besides confirming the fact that spines are lost around amyloid plaques, we also determined whether the spine loss was attributable to a decrease in gained spines or an increase in lost spines.
Knockdown of miR-132 activity in vivo caused a decrease in dendritic spine density, sEPSC frequency, and evoked EPSCs in newborn neurons.
