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In several cell types, there was a decrease in responsiveness to stimulation by certain cytokines (Fig. 2A).
Anhedonia, a core symptom of depression, was modelled by inducing a decrease in responsiveness to rewards reflected by a reduced consumption and/or preference of sweetened solutions.
This is consistent with findings in Drosophila showing that prolonged exposure to an odorant induces structural changes in the antennal lobes correlated with a decrease in responsiveness to that odorant [47].
This could be the result of basic processes such as habituation (non-associative, elemental learning resulting in a decrease in responsiveness to a prolonged or repeatedly experienced stimulus [33]) or sensory adaptation, at the receptor level [34].
For example, a decrease in responsiveness of the small-spiking neuron of rare ECB(E) males to Z12 14 OAc may alter the firing ratio relative to the large-spiking neuron in a way that allows the ACB blend to mimic the ECB(E) blend [22].
Food supplementation results in a decrease in responsiveness of female fireflies (Photinus ignitus) to simulated male flashes [ 24], whereas food restriction results in lower responsiveness and reduced probability of mating in female cockroaches (Nauphoeta cinerea) [ 25].
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This plasticity can be manifested, for example, as a decrease in the responsiveness of individual neurons in the deprived columns, that is, those representing the trimmed whiskers, or as an increase in responsiveness in nondeprived columns (Fox 1992; Glazewski and Fox 1996; Glazewski et al. 1998).
The present study was designed to test the hypothesis that a decrease in the responsiveness of somatodendritic 5-HT-1A receptors by the coadministration of buspirone could reverse the induction of VCMs and supersensitivity at 5-HT-1A receptors by haloperidol.
Finally, repeated exposure to violent media cues lead to reduced psychological and affective arousal by violent media stimuli that is related to a decrease in emotional responsiveness to real-life violence and suffering".
Finally, repeated exposure to violent media cues lead to reduced psychological and affective arousal by violent media stimuli that is related to a decrease in emotional responsiveness to real-life violence and suffering". In other words, among other things, it has been shown to increase aggression and simultaneously decrease empathy, not a good combination.
Upon ligand binding, GPCRs undergo activation followed by a decrease in receptor responsiveness (desensitization).
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