The phrase "a decrease in repressive" is not correct as it is incomplete and lacks a noun to clarify what is being decreased.
You can use it in contexts discussing reductions in repressive measures or policies, but it needs to be part of a complete thought.
Example: "There has been a noticeable decrease in repressive tactics used by the government."
Alternatives: "a reduction in repressive" or "a decline in repressive".
An increase in repressive marks is associated with repression of the PEV reporter gene, and conversely, a decrease in repressive marks is associated with increased expression of the PEV reporter gene among a population of cells [ 25, 26].
These data support the hypothesis that loss of gene silencing of the lacZ and white minigene reporters is likely due to a decrease in repressive heterochromatin with age.
Previous studies reported that progerin leads to a decrease in repressive histone marks including H3K27 trimethylation and loss of peripheral heterochromatin (Shumaker et al., 2006; McCord et al., 2013).
In addition, a depletion of ZEB1 resulted in a decrease in the repressive histone mark H3K27me3 on the miR-203 locus.
In general, there was a strong association between an increase in levels of marks of active transcription (e.g., histone acetylation), a corresponding decrease in repressive marks (H3K27me3 and H3K9me3) and increased transcription levels in Mbd3-null cells.
All three compounds showed a clear decrease in repressive chromatin marks (H3K27me3, H3K9me3), and at least in some instances, an increase in permissive marks, at two target genes (Fig. 3b).
However, a significant decrease in repressive H3K27me3 at genes that escape from XCI suggested that histone modifications still correlate with marsupial XCI [ 56], and may highlight an important difference in escape mechanisms between species.
Two different lines, with the PEV reporter located in the 3L or Y chromosome heterochromatin regions, demonstrated that a decrease in enrichment for repressive marks in heterochromatin [ 23] affects gene silencing in these regions.
In metazoans such an age-related decrease in repressive heterochromatin could contribute to cellular aging as a result of the inappropriate expression from normally silenced genes, non-coding transcriptional units and transposable elements residing in these regions.
We find a loss of gene silencing with age that is associated with an age-related decrease in repressive heterochromatin marks over the PEV reporter, which is opposed by dSir2 and CR.
Our hypothesis is that the observed age-related loss of gene silencing is due to an age-related decrease in repressive heterochromatin in the region of the PEV reporters.
