While most of the studies showed a decrease in local recurrence rate, especially in stage-III/N2 tumors after postoperative radiotherapy, no impact could be shown on overall survival.
We observed a decrease in the recurrence from the third follow-up time point (18 months post-resection; Table 2).
Suggested benefits of MRI include a reduction in margin positivity and conversion from BCS to mastectomy, and a decrease in local recurrence rates.
Consensus level: strong A decrease in local recurrence rates following open ablation compared to other approaches has not been confirmed in all studies.
The MD Anderson series noted a decrease in local recurrence in patients that received adjuvant chemotherapy and surgery, hazard ratio 0.35; (95 % CI 0.15 0.8, P=0.012).
Aspirin use was associated with a decrease in the recurrence of colorectal adenomas in randomised clinical trials (Baron et al, 2003; Benamouzig et al, 2003; Sandler et al, 2003).
A potentially important study is the Nurses Health Studyy, which reported an association between aspirin use and a decrease in distant recurrence and improved survival in women with breast cancer who had survived a minimum of one year following a cancer diagnosis [ 41].
After 1 year, there was a significant decrease in recurrence of ulcers (27.7 vs. 58.3%).
In patients with high AIB1 expression (>75%), there was a significant decrease in recurrence rate (HR 0.40, 95% CI 0.26 0.61, P < 0.001) and breast cancer mortality rate (HR 0.38, 95% CI 0.21 0.69, P = 0.0015) with tamoxifen treatment.
