The phrase "a decrease in receptor" is correct and usable in written English.
It can be used in contexts related to biology, pharmacology, or neuroscience when discussing the reduction of receptor levels or activity in a system.
Example: "The study found a significant decrease in receptor sensitivity after prolonged exposure to the drug."
Alternatives: "a reduction in receptor" or "a decline in receptor".
When ACh was used as an agonist, a decrease in receptor activation was observed for the majority of the mutations.
Prolonged exposure of CA1 pyramidal α7* nAChRs to choline and PNU-120596 may cause neurotoxicity due to a decrease in receptor desensitization and the high Ca2+ permeability of α7* nAChRs.
Such process triggers the production of the proximal inflammation-specific mediator, TNF-a causing a decrease in receptor's sensitivity.
This may be due to a decrease in receptor expression over time.
Upon ligand binding, GPCRs undergo activation followed by a decrease in receptor responsiveness (desensitization).
In addition, such pure antagonists reduce the half-life of ER protein, leading to a decrease in receptor content (down-regulation) [ 30].
Expression profiling of flow-sorted FoxO1-deficient AgRP neurons identified an increase in GABA receptor (inhibitory) expression and a decrease in glutamate receptor (excitatory) expression, as well as the G protein coupled receptor Gpr17 as a FoxO1 target whose expression is regulated by nutritional status (Fig. 5).
This dysfunction of the D1 receptor could be ascribed to the decreased D1 receptor expression and increased D1 receptor phosphorylation because the rosiglitazone-mediated amelioration of the impaired D1 receptor relaxant effect was associated with an increase in D1 receptor expression and a decrease in D1 receptor phosphorylation.
However, these animals still show specific deficits in the glutamate receptor composition with an increase in NMDA and AMPA receptor levels in ProSAP1/Shank2 /– and a decrease in AMPA receptor levels in ProSAP2/Shank3αβ /– mice (Schmeisser et al., 2012).
Lokhandwala et al have found that obese Zucker rats have defective renal D1 receptor function associated with a decrease in D1 receptor expression and ability to inhibit Na, K-ATPase and Na,H-exchanger activities in renal proximal tubules [ 13, 28, 30].
For example, Sheng et al. (26) showed that Hap1 interacts with the GABAA receptor and that reducing Hap1 expression in mouse hypothalamus lead to a decrease in GABAA receptor activity resulting in decreased food intake.
