The phrase "a decrease in nucleotide" is correct and usable in written English.
It can be used in contexts related to biology, genetics, or molecular biology when discussing changes in nucleotide levels or quantities.
Example: "The study revealed a decrease in nucleotide levels, which may impact the overall genetic stability of the organism."
Alternatives: "a reduction in nucleotide" or "a decline in nucleotide".
For example, selection may act to slow the effects of Muller's ratchet by removing slightly deleterious mutations before they go to fixation thereby causing a decrease in nucleotide substitutions rates in older p-endosymbiont lineages.
A decrease in nucleotide substitution rates over time suggests that selection may be limiting the effects of Muller's ratchet by removing individuals with the highest mutational loads and decreasing the rate at which new mutations become fixed.
This loop therefore protrudes within the nucleotide-binding pocket, resulting in a decrease in nucleotide accessibility.
In regions proximal to centromeres, a decrease in the nucleotide substitution frequency was observed, indicating that these regions are subjected to strong selective pressure.
We found an increase of G/C nucleotides and a decrease in A/T nucleotides at the midpoint, as described recently for human cell lines (Valouev et al., 2011).
A decrease in T nucleotides accompanies the increase in A nucleotides in both positions.
The nucleotide frequency distribution over 150 5′-UTR simmediatelyately upstream of the translation initiation codon shows a dramatic increase of nucleotide A toward the translation initiation codon starting from site −40, with a concurrent decrease in nucleotide U.
First, the frequency of nucleotide A increased dramatically toward the initiation codon, with a concurrent decrease in nucleotide U.
In response to hypoxia, the replication arrest has been attributed to a rapid decrease in nucleotide levels, which may in turn be a result of reduced ribonucleotide reductase activity in the absence of oxygen (Pires et al, 2010).
For recombinant norovirus strains, we also observed a sudden decrease in nucleotide identity in the related capsid region (13 ), which represents the outermost protruding domain (P2) and is subject to immune pressure (14 ).
While heterozygosity in each contemporary isofemale lab strain is virtually zero (data not shown), as a whole, these five lab strains collectively only harbor a two-fold genome-wide decrease in nucleotide diversity, Θlab, relative to a large contemporary population from Raleigh NC (Additional file 7: Figure S4).
