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It can also be inferred by a decrease in linkage disequilibrium with increasing genetic map distance [7].
For both synthetic and hospital admissions data, a high level of data cleaning resulted in a decrease in linkage quality.
Recombination causes a decrease in linkage disequilibrium and more recombination is expected between sites that are further apart from each other.
In an additional LD analysis per site, strong but incomplete LD (|D′| Y = 0.9289 – 0.0299X) was detected with a negative slope, indicating a decrease in linkage with increased nucleotide distance (Table 3).
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Nevertheless, mass spectrometry analysis of conjugates formed by CHIP with UbcH5 showed a decrease in forked linkages when S5a was added to the ubiquitination reaction.
Minimal cleaning resulted in a slight decrease in linkage quality for synthetic data, while remaining the same for hospital admissions data.
Thus hydrothermal pretreatment was also found to lead to a decrease in β-O-4 linkages in lignin (i.e., acidolysis of β-O-4 linkages).
Although a peak increase in fine mapping is not a proof that the signal is real, the magnitude of the increase is proportional to the increase in the probability of linkage while a peak decrease is associated with a decrease in the subsequent probability of linkage.
In multivariate models for all respondents (Table 3) and in the sensitivity analysis (Additional file 3: Table S3), respondents' age and prior arrest history were most strongly associated with risk of arrest, and there was a trend toward a decrease in risk associated with a linkage to firearms.
The decrease in linkage disequilibrium with distance for the pre-/early-vaccination sequences is shown graphically in Figure 4.
This pattern is seen for most other transformations, and appears to be the reason for the decrease in linkage quality.
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