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The phrase "a decrease in lifespan" is correct and usable in written English.
You can use it when discussing factors that negatively impact the duration of life, such as health issues, environmental factors, or lifestyle choices.
Example: "The study found a significant decrease in lifespan among individuals exposed to high levels of pollution."
Alternatives: "a reduction in lifespan" or "a shortening of lifespan."
Exact(10)
It seems clear that for some people--perhaps many--having a chronic disease does not cause a decrease in lifespan.
Conversely, decreasing pch-2 expression with RNAi led to a decrease in lifespan.
Notably, only two of the genes tested from this group caused a decrease in lifespan upon knock-down.
These differences did not reflect an increase or a decrease in lifespan but fluctuations in the shape of survival curves.
For this reason, it may be argued that a decrease in lifespan may be found when dj-1β mutation is expressed in a long-lived background (e.g. OR).
Moreover, Drosophila overexpressing Sod2 and catalase, while being significantly more resistant to oxidative stress, showed a decrease in lifespan of up to 43% [ 39].
Similar(50)
Additionally the dhhc-2 mutant showed no change in lifespan, but when knocked down in combination with dhhc-8 there was a decrease in mean lifespan and time to 90% mortality.
The alterations observed are also unlikely to cause any decrease in lifespan of the strain since the few tg-CYP2C18&19 male mice kept as breeders have reached an age of 2 3 years (unpublished data).
Of the RNAi experiments with single genes, dhhc-11 showed a decrease in mean lifespan.
In December 2002 we proposed that a decrease in filter lifespan may be associated with low plasma AT activity.
In addition, aged Nfkb1 −/− animals have increased kyphosis, decreased cortical bone, increased brain GFAP staining and a decrease in overall lifespan compared to Nfkb1 +/+.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com