Exact(5)
Those at the extremes — the very thin and the very fat — showed a decrease in life span.
We observed a decrease in life span with DMSO treatment.
Complementary studies have also shown that increasing the metabolism of honeybees and kestrels results in a decrease in life span (Wolf and Schmid-Hempel 1989; Daan et al. 1996).
The discrepancy of finding of a decrease in life span with the Sir2-1 trandgene and an increase with the Sir2-3 transgene led us to measure the levels of dSir2 expression in these flies.
Deletion of mir-124 in C. elegans resulted in a decrease in life span, an increase in reactive oxygen species (ROS) production, a decrease in ATP levels, and an increase in the aging marker lipofuscin.
Similar(55)
This is equivalent to a 10% decrease in life span.
Overexpression of human wild-type FUS restricted to neurons in Drosophila results in a dose-dependent decrease in life span [ 37], and an impaired locomotor phenotype accompanied by morphological abnormalities in motor neurons and neuromuscular junctions [ 8].
In summary, knockdown of DTK or sNPF with either of the two Gal4 drivers led to a highly significant decrease in life span at desiccation.
While this might be attractive as a possible mechanism for the life span decrease observed in p53-over-expressing females, it is not consistent with the life span increase observed in males; indeed other experiments involving disruption of adult diploid cell function caused an equally dramatic decrease in life span in both sexes [ 35].
Conditional expression of the tra2 RNAi construct in female adults resulted in a small but significant decrease in life span of -12%.
The muscle-specific MHC-GS driver was used to drive over-expression of several transgenes in adult flies, however the MHC-GS driver itself was found to cause a significant RU486-dependent decrease in life span in both males and females (~-20~-20%to-30% and none of the target transgenes tested produced a significant life span increase in this background (Table 3).
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