The phrase "a decrease in leptin" is correct and usable in written English.
It can be used in contexts discussing biological or physiological changes, particularly in relation to appetite regulation or metabolism.
Example: "Research has shown that a decrease in leptin can lead to increased hunger and weight gain."
Alternatives: "a reduction in leptin" or "a drop in leptin levels."
While a drop in insulin also occurs, a decrease in leptin is also necessary for this process to happen, the researchers discovered.
Lack of sleep results in a decrease in leptin, the hormone that makes us feel full, and a surge in ghrelin, which stops us feeling satisfied with the food we do eat.
Further, there is recent evidence that activation of GPCR43 by acetate and propionate causes a decrease in leptin secretion and an increase in adipocyte differentiation [26].
In the current study, we found that the induction of adipogenesis in MSCs was associated with a decrease in leptin secretion and gene expression.
Loss of fat mass will trigger a decrease in leptin.
This reversal is mediated by a decrease in leptin secretion through adipose tissue [ 46].
These findings could imply that a decrease in serum leptin may be one mechanism by which weight loss slows progression of disease in patients with OA.
Although there was a decrease in fasting leptin, an increase in resistin, and an increase in the ghrelin response to a meal, these changes could be a consequence rather than a cause of weight loss (17).
In an adult sleep debt study, short sleep duration led to a decrease in serum leptin and an increase in ghrelin suggesting that short sleep might stimulate appetite and increase food intake [ 11, 12].
In the healthy subjects a decrease in serum leptin concentration appears to stimulate an increase in neuropeptide Y from the hypothalamus and this, in turn, results in increased appetite and decreased energy utilization [ 5].
A decrease in plasma leptin together with a high fat diet suggests an impaired energy balance, which typically leads to weight gain rather than weight loss (Ainslie, Proietto, Fam, & Thorburn, 2000).
