The phrase "a decrease in infarct" is correct and usable in written English.
It can be used in medical or scientific contexts when discussing a reduction in the size or extent of an infarct, which is an area of tissue that has died due to a lack of blood supply.
Example: "The new treatment showed a significant decrease in infarct size in patients with myocardial infarction."
Alternatives: "a reduction in infarct" or "a decline in infarct".
Preliminary results demonstrate an increase in LVEF at 4 and 12 months after infusion as well as a decrease in infarct size [68].
Similarly, global left ventricular ejection fraction (LVEF) improved along with a decrease in infarct size by 40%% in sheep treated with intracoronary infusion of allogeneic bone marrow derived MSCs in comparison to untreated sheep [45].
All three samples showed a decrease in infarct size compared to the control or untreated sample; however the greatest reduction was seen in those transplanted with iCPs, which were derived from adipose tissue stem cells [53].
The overexpression of the survival protein Akt in MSCs led to a decrease in cardiac myocyte apoptosis in vitro and their myocardial transplantation led to a decrease in infarct size [ 41- 44].
The same group has further demonstrated that local delivery of these three transcription factors in murine hearts with coronary ligation can lead to formation of new cardiomyocyte-like cells and a decrease in infarct size [ 40].
Therefore, our data highlight the important role of cytosolic P-GSK-3 β and its physical association to VDAC to preserve the mitochondrial integrity via an attenuation of mPTP opening, thus, leading to a decrease in infarct size.
However, recent studies suggest that not only infarct size [ 30, 51], but also the extent of no-reflow [ 17, 33, 38] is an independent predictor of clinical outcome, which is supported by experimental studies reporting reductions in no-reflow by hypothermia [ 17] or pharmacological intervention [ 27], independent of a decrease in myocardial infarct size.
Assessment of fine motor function revealed that a decrease in initial infarct volume through acute IL-1Ra administration led to enhanced recovery of the original movement ability, whilst animals with delayed IL-1Ra treatment showed evidence of compensation, similarly to the vehicle-treated group.
In previous studies, a marked improvement in survival and a corresponding decrease in infarct volume were observed in transient forebrain ischemia after physical activity on a treadmill for 2 4 weeks in gerbils [ 42], rats [ 45], and mice [ 17].
As compared to their respective controls, TLR4-deficient mice had a diminished brain inflammatory response which was accompanied by a significant decrease in infarct volume and neurological and behavioral alterations [ 35].
We then evaluated infarct healing and demonstrated a significant decrease in infarct size in bmLp-PLA 2 −/− mice 7 days after MI compared with WT.
