The CACACA mutant showed a decrease in half-life to 16 ± 1 min, whereas the CACA and the degODC variants were similar to the wild type psd module (20 ± 1 min), although all three mutants showed decreased stability in darkness (Table 1, Additional file 1: Figure S2 and S3).
In animals a decrease in the half life of erythrocytes and an increase in their fragility [ 50, 51] have been observed.
There was a decrease in elimination half-life (7 20%) and an increase in clearance (30%) after 3-months of daily MeOH exposure compared to the initial exposure.
In addition, rapamycin-stimulated activation of GSK3β leads to a decrease in the half-life of cyclin D1 and induction of cyclin D1 proteolysis [27].
However, the most often encountered situation is an increase in total body clearance during early lactation [ 22] and hence a decrease in terminal half-life of drugs.
Whereas phosphorylation of this residue by PKCδ increased p21 stability, a decrease in its half-life was observed following Ser146 phosphorylation by the atypical PKC ζ.
For THOC7, however, which is a component of the THO complex (67, 68), a multi-protein complex implicated in the coupling of transcription and mRNA processing, a decrease in protein half-life could be observed.
A rifampicin time-course experiment suggests that the observed increase in the abundance of the pause species is due, at least in part, to a decrease in pause half-life.
A significant decrease in half time of total aggregation (T1/2) and a rise in aggregation index (AI) after exercise were observed; however, after the postexercise period these changes were reversed.
Treatment of 16 patients with a monoclonal anti-CD22 antibody, epratuzumab, resulted in improvement of unstimulated whole saliva production and a decrease in fatigue in one-half of the patients.
