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Decreased inhibition was related to a decrease in glutamine synthetase, the enzyme that converts glutamate to glutamine and ultimately to GABA in inhibitory terminals.
Cadmium treatment of adult animals caused a decrease in glutamine content, as compared to controls.
In both roots and xylem sap after NH4+ supply, rice mutants lacking GS1 2 showed a decrease in glutamine and asparagine content, while mutants lacking AS1 showed a decrease in asparagine content (Funayama et al. 2013; Ohashi et al. 2015a).
In this study, GC-TOF-MS analysis revealed a decrease in glutamine levels in the sera of patients with psoriasis when compared to healthy controls.
The assimilation of ammonium was also affected but to slightly different extents depending on the tissue, with a decrease in glutamine and glutamate synthases transcripts in stem and root and an increase in leaf.
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Inhibition of mTOR activity by rapamycin or blocking S6 expression by siRNA inhibited GDH and GLS activity, leading to a decrease in glutamine-induced cell proliferation.
In this experiment, the elevated levels of proline were accompanied by a slight decrease in glutamine levels (data not shown), but the total levels of proline, glutamine, and glutamic acid, which are metabolically interrelated, were higher in the stressed tissues.
In the present study, LPS infusion was found to instigate a decrease in the arterial glutamine levels, and a cerebral glutamine efflux accompanied this.
Thus, the decrease in glutamine content caused by a lack of GS1 2 is suggested to result in low expression of OsAS1, decreasing asparagine content.
This decrease in glutamine content in the basal portions of shoots caused a deficiency of active cytokinin, which is required for the outgrowth of rice tillers, via the down-regulation of glutamine or its related metabolite-dependent cytokinin synthesis (Ohashi et al. 2017).
Consistently, the cells showed robust decrease in glutamine consumption in response to MTOB treatment.
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