The phrase "a decrease in flexibility" is correct and usable in written English.
It can be used when discussing a reduction in the ability to adapt or change, often in contexts related to physical, mental, or organizational flexibility.
Example: "The new policies have led to a decrease in flexibility for employees, making it harder for them to balance work and personal commitments."
Alternatives: "a reduction in adaptability" or "a decline in versatility."
In other words, the interaction with ERK2 leads to a decrease in flexibility of the N-terminus of PTP-SL within the complex and implicitly, a decrease of entropy.
The presence and importance of these changes within the ribosome are unknown, although it is tempting to speculate that a decrease in flexibility may drive the defects observed in this study.
The decrease in flexibility values was in consonance with the results obtained in endurance runner, who presented a decrease in flexibility values because of musculotendinous structures reducing the aerobic demand of submaximal running by facilitating a greater elastic energy return during the shortening phase of the stretch shortening cycle [ 10].
Remarkably, the binding of Raf-RBD to wild type HRas promotes a decrease in flexibility of residues that coordinate Ca2+ at the remote allosteric site, adding to our proposed mechanism that interaction with the membrane primes the site for calcium binding to enhance intrinsic hydrolysis in the complex with Raf [ 3].
There is evidence for a decrease in flexibility of this loop in the complex, notably at residues Thr173(226) and Ser174(227); in the free enzyme the bundle of structures is divided into two subgroups of different backbone conformation for residues 173 174 creating the high local RMSD values.
This motion does not appear to be accompanied by any decrease in flexibility; the local backbone RMSD of the loop residues does not change significantly upon inhibitor binding.
A decrease in conformational flexibility may be the basis of the mercurial-induced diminution in activity of the enzyme during steady-state turnover conditions.
Alternatively, this constellation of prolines and charged residues may contribute to a decrease in the flexibility of this segment and, in turn, enhance the antagonistic effects of the deletion on the efficiency of α-cleavage.
Recently, a molecular dynamics simulations study explored the interactions of the EEA1-FYVE domain and verified that it undergoes a decrease in dynamic flexibility upon binding to its PtdIns(3) P ligand and a phospholipid bilayer [ 29].
Clearly, this has implications for pathological cardiac hypertrophy, characterised by a decrease in metabolic flexibility and increased reliance on glucose metabolism and glycolysis for ATP synthesis in an oxygen-sparing manner.
A decrease in segmental flexibility was also reported to be associated with disc degeneration and the biomechanical effect of degenerative disc changes on the disc pressure was higher in lateral bending condition.
