The phrase "a decrease in dense" is not correct in written English.
It seems to be an incomplete thought, possibly intended to refer to "a decrease in density" or something similar.
Example: "The study showed a decrease in density of the material over time."
Alternatives: "a reduction in density" or "a decline in density."
Therefore, the larger decrease in percent density in women who gained weight than in women who remained stable or lost weight can probably be explained by changes in nondense area and not by a decrease in dense area.
However, the association between weight or BMI and dense area showed contrary results: Woolcott et al. found that a decrease in BMI was correlated with an increase in dense area, whereas Boyd et al. found that weight loss was associated with a decrease in dense area, and we did not find an association between changes in weight and dense area at all.
In a murine study, exposure to estrogen prior to puberty led to a decrease in radiologically dense tissue and an increase in the number of radiolucent structures [ 28], which may be analogous to a lower mammographic density in humans.
Among women with <3.0% TC risk, a decrease in absolute dense volume was found for women with any higher levels of total activity compared with the lowest level (<40.0 MET-hours/day).
However, a decrease in absolute dense volume was only seen among women with 3.0 to 4.9% TC risk performing 45.0 to 49.9 or ≥50.0 MET-hours/day and only in women with ≥5.0% TC risk engaging in ≥50.0 MET-hours/day, as compared with the lowest category.> -wrap-foot> β, regression coefficient; CI, confidence interval; MET, metabolic equivalent of task.
Nevertheless, LDL particles in this group were more atherogenic as testified by a decrease in small-dense LDL size that was counteracted by grape PPs (29).
We found a median decrease in dense area of 12.4 cm in 5 years (IQR of −25.1; −4.1), whereas Woolcott et al. found a change of only −0.1 cm (IQR of −4.1; 3.2) over 1 year.
In contrast, a 2-year intervention study using a low-fat high-carbohydrate diet observed that, while there was a decrease in the mammographic dense area associated with weight loss, the percentage of density actually increased [ 44].
This is in contrast to the findings of Destounis and colleagues and of Ho and Lam, who reported a decrease in CAD sensitivity in dense breasts [ 53, 54].
In a longitudinal study, women with higher levels of serum IGF-I during the premenopausal period experienced a smaller increase nondense area and a slightly smaller decrease in dense area during menopause [ 40].
On the other hand, ZAP and CTBA present a decrease in their performances in denser topologies.
