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The expression of the inhibitor increases during the early 'aggregation' phase, followed by a decline of expression at late stages when antigens are further processed and presented on the cell surface.
On the other hand, Vv TFL displays a decline of expression in stages D and G whereas VvLFY and VvAP1 show an increase in transcription abundance.
In addition to the genes up-regulated after U. maydis infection, there are also some ZmLTP genes show a decline of expression levels as time goes by, such as ZmLTPg23 and ZmLTPd6.
This time course correlates with a higher expression of the caNrf2 transgene in adult compared to newborn mice and with a decline of expression in aged mice (Supporting information Fig S1B).
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Both C1A and SAHA were associated with a decline of CDK4 expression, consistent with HSP90 inhibition.
Our data demonstrating a decline of OPN expression after 24 hours of treatment with MSC is suggestive of a role for selenium in the attachment and migration of TM6 cells in vitro.
Interestingly, we also observed a decline of the expression of the three core components of the polycomb repressive complex 2 (PRC2, a major epigenetic regulator) eed, ezh2 and suz12 to different extent (Fig. 4).
Previous studies have shown a decline of ERβ1 expression from ductal carcinoma in situ (DCIS) to invasive cancer and an association of the receptor with the repression of mesenchymal characteristics in invasive prostate cancer [ 22, 30, 31].
In addition, certain clusters of genes, once activated, maintain their activity when the tissues grow older while other clusters are characterized by a decline of their expression in the older nodule cells.
The importance of Puf-A in the maturation of germline stem cells was also implicated by its unique expression in the most primitive follicles (stage I) in adult ovaries, followed by a sharp decline of expression in later stages of folliculogenesis.
Under continuous HNE exposure, IL-1β exhibited a biphasic decline of expression whereby at low concentrations of HNE (0.01−0.5 μM), there was a gradual loss of cytokine expression to about 80% of DMSO control.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com