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The phrase "a damaging blow when" is correct and usable in written English.
It can be used to describe a situation where something negative or harmful occurs at a specific time or under certain circumstances.
Example: "The company faced a damaging blow when their main supplier went out of business unexpectedly."
Alternatives: "a severe setback when" or "a significant loss when".
Exact(3)
Attempts to prosecute Slahi before a military commission suffered a damaging blow when one of the prosecution team, Lt Col Stuart Couch, refused to play any part.
In February 1994, the White House suffered a damaging blow when the Congressional Budget Office said that the Clintons had understated the cost of their proposal and the premiums needed to pay for it.
One of Britain's leading architects – the firm behind the Scottish Parliament, Abu Dhabi's striking Capital Gate and Europe's tallest building, the proposed Gazprom Tower in St Petersburg – suffered a damaging blow when its managing director quit shortly after embarrassing emails criticising him were leaked.
Similar(57)
The prime minister only narrowly avoided a damaging blow in his neighbouring constituency of Glenrothes in November when the Scottish National party increased its share of the vote by 13.1%.
A damaging blow to peace efforts in the region was delivered in October when General Nkunda announced that he intended to transform the CNDP into a national movement aimed at liberating the whole country.
The US supreme court has dealt a damaging blow to Barack Obama's presidency by unanimously ruling that he overstepped his constitutional powers when he filled high-level government vacancies without consulting the Senate.
It would be a damaging blow to NATO".
Vice President Al Gore denounced such a move, saying it would deal a "damaging blow" to NATO.
But I don't see this as a damaging blow to the government's case".
It has also dealt a damaging blow to Kenya's vital tourism business.
He also thanked the United States for carrying out the strike, saying it had delivered a damaging blow to Isis.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com