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Cell seeded collagen constructs were mechanically stretched by a daily application of cyclic uniaxial strain using a special motor-driven apparatus and compared to unstretched controls.
The corticosterone treatment consisted of a daily application of 4.5 µl of sesame oil mixed with corticosterone (3 µg of corticosterone/µl oil [55]).
The occurrence of any abiotic or biotic stress was minimized by a daily application of nutrient solution and prophylactic measures to prevent the presence of any pest in the climatic chambers.
The control group (8 patients) was treated under similar conditions, except with a daily application of vehicle instead of retinaldehyde.
In addition, it was shown by scanning electron microscopy (SEM) that calculus (firmly bound to hard dental tissue) could develop on dentin specimens subjected to an in situ carious attack with a daily application of a 50% sucrose solution in individuals living in a water-fluoridated area for periods of four weeks.
Both the treatment group and the control group received a daily application of solvents for a period of one week with the control group receiving solvents only while the solvents of the treatment group also included the triple therapy of Upamostat®, Celecoxib® and Ilomastat®.
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The patient was counselled regarding the benign nature of the disease and started on a twice daily application of a potent topical corticosteroid (clobetasol propionate 0.05%) ointment.
6 An initial study by Stockfleth et al investigated the use of a once daily application of 5% imiquimod cream 3 times a week for 6 8 weeks on six patients with actinic keratoses located on the scalp.
These first trials indicated that imiquimod could be an effective treatment for sBCC and that an appropriate treatment regime would be a maximum of a daily application, higher dosing causing more and intolerable side effects.
Basis for the updated recommendations: In addition to the previously available clinical trial data, a small study confirmed that a one to two-week daily application of an hydrocortisone aceponate spray (Cortavance, Virbac) significantly improved lesions and pruritus in atopic dogs (QOE 2) [ 10 ].
An editorial published in the same issue, Oct. 25, said the laser was about as effective as a more standard treatment, daily application of benzoyl peroxide, which is often combined with antibiotics.
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