Sentence examples for a cycle of damage from inspiring English sources

The illicit distilleries, in other words, were emblems of both criminality and victimhood — belonging to a cycle of damage that grew as it caused more people to commit more ecological harm.

Heart failure is not a single entity, but a cycle of damage and neurohormonal activation that begins with an adverse cardiovascular environment, causing or leading to cardiac injury.

This inflammatory state in glial cells leads to the production of toxic substances, including cytokines such as IL-1β, IL-6, and TNF-α, that further damage neurons, leading to a cycle of inflammatory damage that ultimately worsens the progression of the disease.

When mitochondria are damaged, superoxide generation by the electron transport chain complexes I and III is enhanced, leading to the production of more ROS and thereby setting up a cycle of cellular damage (Finkel and Holbrook, 2000).

Additional superoxide resulting from initial BH4 oxidation and NOS uncoupling would promote a cycle of cellular damage, further BH4 oxidation and biochemical stabilization of uncoupled NOS activity (Fig.  1).

However, there also seems to be increased XO activity in the failing myocardium, perhaps due to hypoxia and apoptosis, resulting in accumulation of uric acid precursors (hypoxanthine and xanathine) and XO-induced production of ROS, causing a vicious cycle of damage [ 43].

Together, these data have led to the idea that prelamin A/progerin accumulation interferes with the loading of DNA repair proteins to DSB sites and that, as a consequence, irreparable DNA damage remains which fuels a cycle of chronic DNA damage response, premature senescence and aging.

During prion disease, increased superoxide due to the conversion of PrPC to PrPSc, coupled with a loss of SOD2 and therefore its antioxidant activity, might begin a cycle of heightened oxidative damage within mitochondria, eventuating in their loss.

A mechanism by which Pb exposure may increase the susceptibility of osteoblasts to environmental toxins has recently been proposed [ 46], and it may be that regardless of causality, once the Pb levels are increased, a cycle of increased susceptibility to toxic damage may begin.

"We are both familiar with domestic violence and the cycle of damage it causes," they said in a joint statement.

If this cycle of damage and regrowth — what ecologists call a disturbance regime — occurs more often as extreme storms become more frequent, some forests may never recover completely.