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The programs to extract the core dictionaries (Steps 4 7), to construct the semantic map (as described above), and to analyze the results, were custom implemented using a combination of GNU C (GCC 4.2) and Matlab along with their standard libraries and functions (all code is available upon request).

The MRI stacks were processed with a custom toolbox, implemented using open source software.

We conducted single marker and haplotype TDT association analysis using a custom script implemented in R statistical software and based on Transmit [14], and the equivalent FBAT approach [15] for comparison of the results.

The feature selection was completed using a custom script implemented in SAS.

Jarvis Patrick clustering was performed with a custom program implemented in C++.

} Then, a custom algorithm implemented in JAVA is used to count the number of common AGROVOC URIs between the AGRIS entity and web URLs returned by the previous query, storing the top 20 most relevant web resources in the Recommender Database.

A custom script implementing strict quality filters based on the provided base call quality scores was used to trim sequences reads prior to assembly.

A custom-implemented function (T. Frickey, personal communication) was used that allows for exclusion of similar sequences from the dataset based on the taxonomic level (i.e. only one sequence is retained as a representative of all Bacillus sequences above a set identity).

As a capability that could be integrated into a custom user interface implemented for a specific project.

This calculation was done on a genome-wide scale using a custom script that implemented a divide-and-conquer algorithm, and which is available upon request.

We have amended the following text to make this clear: "The pre-processed MEG data were projected onto a regular 8 mm grid spanning the entire brain using a custom scalar beamformer implemented in SPM8".

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