We hypothesise that medication overuse headache is a specific form of opioid-induced hyperalgesia, which derives from a cumulative interaction between central sensitisation, due to repeated activation of nociceptive pathways by recurrent headaches, and pain facilitation due to glial activation.
The aesthetic theorist John Dewey, wrote that "An experience is a product, one might almost say bi-product, of continuous and cumulative interaction of an organic self with the world.
The hierarchical system of recognition in nature is based on interaction between the smallest elements in a matrix such as molecules and the cumulative interactions of larger parts such as the helices and sheets of proteins.
This suggests that the cumulative interactions of many genes orchestrate both overall lifespan and patterns of healthy ageing.Despite this strong genetic evidence, ceding longevity entirely to biology would be premature.
As evidence of this cumulative interaction, the documented genesis of the epidemic in 2003 occurred in the area where the host density is lowest and subsequently spread into adjacent areas (Sodankylä) in 2004 and 2005 (Tt 12.9 and 14.3°C, respectively (Database of Finnish Meteorological Institute) where reindeer were considerably more abundant (Laaksonen et al., 2008b).
Environmental pollution mitigation is a cumulative effect of plant microbe interactions in a broader sense Pilon-Simts and Freemann 2006), also commonly known as bioremediation, which has been the most researched field in biological and environmental sciences all over the world.
Under these circumstances, it is concluded that the interplay of these three interactions, namely super-exchange interaction, magnetocrystalline anisotropy, and canting effect, is more prevalently present in the nanoparticles of ferrite, and hence the magnetic property observed in the system of nanoferrites is a cumulative effect of these interactions.
A regulatory network was defined as a cumulative representation of all interactions between TFs and their known target genes, one or both of which was represented in the DEG list.
A critical lesson from the case study data is the importance of relationships in the recruitment process for large population-based studies, and the need for ongoing documentation and analysis of the impact of cumulative interactions between research and community engagement.
