The phrase "a crucial modification" is correct and usable in written English.
It can be used when discussing an important change or adjustment that significantly impacts a situation or outcome.
Example: "The team implemented a crucial modification to the software that improved its performance dramatically."
Alternatives: "an essential change" or "a vital adjustment."
Mr Bowling attributes Polaris's stronger performance to a crucial modification that allowed the program to adjust its strategy in response to its opponent's behaviour during a match.Polaris has not competed against humans since then, but the CPRG has done some work on another poker variety, heads-up no-limit Hold 'em.
Glycosylation is a crucial modification of many secondary metabolites, but is a challenging reaction to perform at a larger scale.
This paper is focused on preparation and determination of physicochemical properties of new composite glass protonic membranes (P2O5 SiO2 TiO2) with the addition of PVA which could be a crucial modification for their application as electrolytic materials in fuel cells operating in the temperature range 30 150 °C.
ATR also acts to repair by, for example, controlling the ubiquitination of DNA repair-associated proteins such as FANCD2, a crucial modification required for FANCD2 localization to the DNA damage foci close to the recombinational repair protein BRCA2 [38].
This is a crucial modification of Boyd and Richerson (2002) where the core assumption is that there is are two norms, both stable when common.
Further, histone H4 acetylation by Tip60 is important for the alteration of nucleosome stability during DNA damage repair [ 55]; Tip60 also acetylates γ-H2A.X, a crucial modification for the turnover of γ-H2A.X after repair [ 56].
In fact, the most common disease-causing mutation, the A3243G alteration that is implicated in MELAS disease, results in the absence of a crucial taurine modification at position 34 without any change in other modifications, possibly because A3243G selectively alters the folding pathway.
The acetylation of the lysine side chains is a crucial posttranslational modification in numerous proteins and has crosstalk with phosphorylation, methylation and other covalent modifications, leading to dynamic signaling networks (Freiman and Tjian, 2003; Yang and Seto, 2008).
DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes.
In this context information is missing about DNA cytosine methylation as a crucial epigenetic modification and an important element in mammalian genome regulation and development.
N-myristoylation is a crucial covalent modification of numerous eukaryotic and viral proteins that is catalyzed by N-myristoyltransferase (NMT).
