Sentence examples for a cross presentation from inspiring English sources

We did not analyze whether a cross presentation of antigen to CD8 T cells was present in our system, but we can not exclude this possibility, since the plasmid DNA interfered with the pH of the late endosomal/lysosomal compartment in different antigen presenting cells.

Moreover, APCs have a cross-presentation system that presents endocytosed foreign proteins with MHC-I to activate CTLs [ 17].

Therefore, we studied the ability to stimulate HIV- and vaccinia-specific CD8 T cells in a cross-presentation assay in which moDCs present antigens from apoptotic, infected HeLa cells.

19, 20 The two pathways are not separated, and antigens that are mainly processed by one class of HLAs can be presented by the other via a cross-presentation pathway.

Towards that end, a cross-presentation assay was developed to determine the ability of moDCs to cross-present antigens from apoptotic infected HeLa cells.

The ultimate outcome is a classical antigen presentation in major histocompatibility complex (MHC) class II but also a cross-presentation in MHC class I molecules to prime CD4+ T helper as well as CD8+ cytotoxic T cells.

The presentation of this peptide on class I molecules by human melanoma cells required a cross-presentation mechanism.

Since recombinant Gag/Δpp65-VLPs share the particulate nature with these antigens, a cross-presentation pathway might also exists for them as well as for pp65 associated to intact HCMV virions (present in the positive control).

Indeed, enhanced HIV transgene expression was observed in moDCs, as well as HeLa cells, which in turn correlates with robust cytokine production by HIV-specific CD8 T cells in a cross-presentation assay.

Since the observed increase in T cell response was based on priming by γ-irradiated cells, it was possible that DCs play an important role in antigen uptake from the apoptotic cells for T cell priming via a cross-presentation pathway.

Further studies in human preclinical studies and in vivo studies using HLA class I transgenic mice showed TAA-derived long peptides (TAA-LPs) have the capacity to induce not only promiscuous HLA class II-restricted CD4+ T helper type 1 cells but also tumor-specific CTLs through a cross-presentation mechanism.