The phrase "a critical tether" is correct and usable in written English.
It can be used to describe an essential connection or link that is important for stability or support in a particular context.
Example: "In times of uncertainty, family can serve as a critical tether that keeps us grounded."
Alternatives: "an essential link" or "a vital connection."
The complete lack of cohesion between plasmalemma and IMC in the stage-specific knockdown mutant demonstrates that GAP45 is a critical tethering factor between these membranes and provides a striking confirmation of recent findings from a tetracycline-induced knockdown in T. gondii tachyzoites (Frénal et al., 2010).
Previously, we defined the amino-terminal 17 amino acids of huntingtin as a critical ER tether that mediates its release from the ER upon stress (9).
These results seem to rule out a critical role for tethering in TPE (Ferreira et al. 2011).
PREP114 encodes selectin P ligand (SELPLG), which stimulates T lymphocytes, and plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin.
Tyrosylprotein sulfotransferase (TPST) transfers sulfates to the P-selectin glycoprotein ligand-1 (PSGL-1) on myeloid cells and stimulated T lymphocytes and plays a critical role in the tethering of these cells to activated platelets or endothelia that express P-selectin [ 23].
Severe ADAMTS13 deficiency (activity generally < 10%) results in insufficient processing of von Willebrand factor (VWF) — a critical mediator of normal platelet tethering.
In the large genomes of vertebrates, where extensive global control regions have been identified, promoter-enhancer tethering is emerging as a critical general mechanism for regulation of gene expression [3], [37].
The Atg8-PE covalent structure (LC3 II in mammals) confers Atg8 membrane tethering and hemifusion ability and plays a critical role in autophagosome formation.
Pam18 is tethered to the inner mitochondrial membrane and is required for the translocation function, whereas Mdj1 plays a critical role in the folding of precursor protein in the matrix (23– 23).
Since the tether cannot yield a torque along itself and the TM motions are constrained, the underactuated problem subject to input saturation arises as a critical control challenge.
