The phrase "a critical player of" is not correct in standard English; it should be "a critical player in." You can use it when referring to someone or something that plays an essential role in a particular context or situation.
Example: "She has been a critical player in the success of the project, contributing valuable insights and leadership."
Alternatives: "a key player in" or "an essential contributor to."
Little is known about the effect of MSC on macrophages, a critical player of the innate immune response involved in almost all immune-mediated diseases.
We propose that leptin is a key regulator of the malignant properties of hepatocellular carcinoma cells through modulation of hTERT, a critical player of oncogenesis.
Most importantly, the expressions of the genes encoding for the early maturation marker TRAP (Acp5), the most plausible PLCγ2 effector NFATc1 (Nfatc1) [ 11, 31] and of DC-STAMP (Tm7sf4), a critical player of the preosteoclast fusion machinery [ 37, 38], were all upregulated normally in PLCγ2−/− cultures (Fig. 4b).
In fact, we observed a significant down regulation of desmin (Fig. 4C), a marker of proliferating satellite cells (Musaro, 2014, Rantanen et al., 1995), and a significant up-regulation of myogenin (Fig. 4D), a critical player for the terminal differentiation of myoblasts (Hasty et al., 1993, Musaro, 2014, Nabeshima et al., 1993).
p130Cas is thus emerging as a critical player for onset and progression of many aggressive cancers, strengthening its relevance as an unfavorable prognostic marker and a putative therapeutic target, mostly in combination with high levels of ER, HER2 or Cox-2, respectively.
Meanwhile, oligomerization of VHL-SUMO1ΔC4 was enhanced by PIASy coexpression (Figure 3B), and reduced by lentivirus-mediated loss of endogenous PIASy (Figure 3C, D), which highlights the role of PIASy as a critical player in oligomerization of SUMOylated VHL.
In this respect identification of PLCγ1 as a critical player in regulation of FGF-induced EC migration and tubulogenesis and in modulating Akt activation will have both biological and potential therapeutic implications.
This analysis revealed striking similarities between Cr2Tf, In2Tf and Ti2Tf on one hand, and the diferric form of Tf on the other hand, strongly suggesting that Tf is indeed a critical player in homeostasis of these metals and must be considered both in the analysis of metal toxicity and in the design of metal-based therapeutics.
If confirmed, this protein would not only be linked to male reproductive senescence, but also as a critical player in one of the postmating, prezygotic phenotypes that isolate species in this complex of crickets.
Gro is a critical player in many of the pathways that regulate wing development including the Notch, Ras, and Dpp pathways [45], [46].
The stability of this particular MAPK seems to be controlled by c-Abl and Bcr/Abl and also has been postulated to be a critical player in terms of de novo resistance [2].
