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Smoothing elastoplastic stress strain curves obtained by a critical modification of conventional models.
H3K56ac is a critical modification for nucleosome assembly in yeast35,36 and the S57 residue in H3.3 is replaced by alanine in H3mm7.
Proteolysis is a critical modification leading to alteration of protein function with important outcomes in many biological processes.
Knockout of Suv39h1 and Suv39h2 in mouse results in widespread genomic instability and increased incidence of lymphomas, suggesting that 3MeH3K9 is a critical modification to maintain chromosomal environments [2].
Here we now report about a critical modification of the MTT assay, which allows assessment of organoid survival using both qualitative morphological parameters as well as quantitative colorimetric measurements.
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Our results provide evidence that p300/CBP-mediated acetylation may be a universal and critical modification for p53 function.
Glycosylation is a critical protein modification relevant to numerous physiological functions and cellular pathways.
These studies strongly suggest that HsMCM3 phosphorylation is a critical posttranslational modification that regulates assembly and activity of the HsMCM2 7 complex.
DNA methylation is a critical epigenetic modification of the genome and is involved in regulating many cellular processes including gene expression and genomic stability.
DNA methylation is a critical epigenetic modification of the genome that controls many biologic processes, including embryonic development, X chromosome inactivation, imprinting, and gene expression [ 45, 46].
This form of protein fatty acylation is emerging as a critical regulatory modification for multiple aspects of cellular interactions and signaling.
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