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The phrase "a critical difference is that" is correct and usable in written English.
It can be used to highlight an important distinction between two or more subjects or ideas.
Example: "When comparing the two theories, a critical difference is that one emphasizes individual behavior while the other focuses on societal influences."
Alternatives: "a key distinction is that" or "an important difference is that".
Exact(5)
A critical difference is that they can move around.
But to me, what makes a critical difference is that in the jardins, you can find the greatest piece of (urban) furniture on earth – the reclining Chaise Luxembourg.
A critical difference is that the boundary nodes at the top which receive a large score with BVA but are given minimal importance with betweenness.
A critical difference is that in a land-based system, the power provider frequently does not own the loads so load shedding is a negotiation, generally done in advance, or a complete shutdown is necessary.
A critical difference is that high NaCl inhibits DNA repair [27], inhibiting activation of DNA repair proteins, like γH2AX and reducing recruitment of the MRN complex to foci at the breaks [32].
Similar(52)
A final, and critical, difference is that we collected multiple samples from each subject to develop an EBC pH profile, and this profile allows for much greater sensitivity of the procedure by enhancing the likelihood of finding a correlation of cough with acidity if it is indeed present in a given patient.
A critical difference is the fact that in our study, the native peptide is metabolized to the active metabolite, GLP-1 (9–36), which we [ 35] have shown to be biologically active, particularly vasoactive.
MOOCs are not the same as traditional credit-bearing online course, as Joshua Kim points out on Inside Higher Ed. "The critical difference is that a well-designed online course is built around the co-construction of knowledge amongst the students and the instructor," Kim writes.
The only critical difference is that an approximation result of [14,30] is needed to localize the H 1 / 2 - norm in (26), since H -functions on 2D manifolds can be discontinuous.
Hence, the critical difference is that model-based methods implicitly enforce a protocol, but, in their patient-specificity, translate the "one size fits all" approach of a fixed protocol to a "one method fits all" patient-specific form of care.
The critical difference is that the next Batmobile, the Tumbler, is a military vehicle, and perhaps just the right reflection of the state of the world now.
More suggestions(15)
a critical thing is that
a critical caveat is that
a notable difference is that
a critical aspect is that
a critical distinction is that
a critical finding is that
a critical lesson is that
a distinct difference is that
a second difference is that
a critical limitation is that
a critical problem is that
a critical observation is that
a critical concept is that
a further difference is that
a huge difference is that
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com