Emerging evidence suggests that the T790M 'gatekeeper' mutation may exist in lung tumours before EGFR-TKI therapeutic selection (Bell et al, 2005; Godin-Heymann et al, 2007), partly due to its enhanced oncogenicity, and accounts for the adverse clinical course and outcome in gefitinib/erlotinib-resistance lung cancers after a course of rapid TKI selection.
This pattern is also consistent with a rather slow change in allele frequencies at QTL during the course of selection or a gradual release of selectable additive genetic variation from the epistatic loci [ 21].
The consistent evolution of diversity in independent microcosms is notable, considering that any diversity within microcosms evolved de novo via mutations arising during the course of selection in a relatively simple, well mixed, two-resource environment, and indicates that diversification within microcosms was itself adaptive.
In this article, he is primarily concerned with modeling the course of selection processes, and he offers a species-level selection interpretation for an aggregate species-level trait (Dawkins 1989a).
During the course of selection, RD cells were split when a 70% 90% confluence was reached.
We observed an allele of Cys2 that was enriched from 8%to29%9% in the course of selection for HM, while it was reduced to 0% in the course of selection for LM.
The sexual line maintained sexual efficiencies of up to 50% over the course of selection.
Over the course of selection, deleterious alleles can be replaced by less-deleterious alleles with similar phenotypic effects.
To eradicate these molecules in the course of selection, we first characterized them and then modified the selection scheme accordingly so as to reduce their chances of survival.
In the course of selection, we obtained 2,987 interaction sequence tags (ISTs), which were subjected to BLASTN searches to identify their corresponding proteins.
