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The resulting peptide, WKYM, represents a core structure for an FPRL1 ligand.
Megazol is a highly active compound against Trypanosoma cruzi, and has become a core structure for the design of new trypanocidal agents.
Overall, the data indicate that the presented chemotype could serve as a core structure for the design of putative pharmacotherapeutic agents, aiming to the long-term complications of diabetes mellitus.
These results clearly indicate that the phenol group is a core structure for the attachment of BPA to ERR-γ.
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If indeed a core structure is necessary for maturation of the rRNA, mutations in a minimum length structure will affect the core structure integrity moreso than longer ITS2 sequences that may accommodate a higher level of mutation.
The use of a service core structure for the building minimised the number of internal columns were needed, with only two on the largest floors, which maximised usable space.
In addition, analysis of domain architecture of P. syringae HKs showed a conserved core structure for each HK type in P. syringae.
The α-ketoamides displayed a significant enhanced potency relative to their parent isosteres as inhibitors of HIV-1 protease and are shown to be a promising new core structure for the development of enzyme inhibitors.
This series featured a rigid tricyclic ring system as an important pharmacophore core structure for high binding affinity.
Thus, likely the benzothiazole linked to a triazine ring backbone may be the core structure for binding to and inhibiting ABCG2 function and stability.
The virtual test results reported in this paper can provide researchers with a general guideline to design the most suitable folded core structure for certain applications.
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