T-emerge 2 was a randomized, open-label, active-comparator, parallel-group, phase 3 trial with a 24-week core phase, a 28-week extension phase, and an optional 104-week, long-term extension phase; the trial was conducted at 189 sites in 23 countries.
Specifically, we consider TWCSs with a neo-Hookean core phase and a stiffer or a softer shell subjected to simple shear displacement and traction boundary conditions.
Patients were followed-up during a 6 months core phase with an optional follow-up for up to 12 months in total.
A particulate core shell solid dispersion was designed using poly methacrylic acid-co-methyl methacrylate) (Eudragit L-100) as a shell material and poly vinyl pyrrolidone) K12-17 as a dispersant for FEN in the core phase.
"The one time you really don't want to get pregnant is when you're single and the other person is married and you're working as a first-year junior associate at a law firm in a hard-core phase of trying to prove yourself to them," Ms. Greenfield recalled last week.
A total of 366 patients (87% female, mean age 41.8 ± 11.6 years) were eligible for migraine prevention and treated with flexible dose topiramate for 6 months (core phase), and optionally for a total of 12 months (follow-up phase).
The results of a T-jump experiment through the neutral lipid core phase transition of LDL are shown in Fig. 3A, and for better illustration, the changes in the integrated intensities of the first side maximum are depicted.
Because the core phase of our study has been scheduled for a maximum of 3 years at study initiation, an extension phase is now planned in order to collect follow-up clinical data of the study cohort (progression index, time to conversion to clinically definite and chronic-progressive MS).
A 2-level factorial experimental design was employed to investigate the effect of hydroxyl (core phase), carboxylate (shell phase) groups, and type of surfactant (Triton X200, Tergitol XJ) on the mechanical properties of thermosetting latexes.
