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For the EGFR pathway, we considered two representations: a "core" pathway with 11 proteins (Biocarta) and an "expanded" pathway with 47 proteins (HPRD).
A core pathway for RdDM in A. thaliana has emerged from genetic analysis (Fig. 7).
S metabolism is a core pathway for the synthesis of molecules required for some environmental stresses including Al [ 4, 10].
At 1 hr, many shared target genes show similar ERK or PI3K dependence, possibly constituting a core pathway specific gene set.
As one of examples, M00009_1 is a core pathway module for the TCA cycle comprising 8 reactions as shown in Figure 2A.
Overall, we conclude that this novel LRH-1 pathwaythway represents a core pathway that is required for hepatic ER stress resolution.
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The DACCP uses staff skills and time effectively via a structured core pathway to provide a consistent, up-to-date, evidence-based approach to the treatment and management of children and adolescents with ADHD.
Models 3 and 4 used the protein sites in the EGFR pathway from two sources: a smaller core pathway protein set from BioCarta (www.biocarta.com) and a larger EGFR related protein interaction network from HPRD/NetPath [41].
Importantly, inactivation of autophagy in kidney and lung fibrogenic cells also reduced their capacity to drive a fibrogenic response [ 32], identifying autophagy as a potential core pathway of fibrogenesis.
The pathway that appears more frequently than by chance is a potential core pathway.
The linear case has a single core pathway, with participants being redirected back to the core pathway irrespective of the decision made, for example by feedback from a supervising clinician in the case.
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