Cell movement is typically associated with a coordinated assembly and disassembly of the cortical actin network (Cunningham et al, 1991, 1992).
However, cell migration does not only require a coordinated assembly and disassembly of FAs to move the cell body on the ECM, but also needs active actin polymerization along the plasma membrane to contract the cell cortex.
"But when multiple neurons spread all over the brain are tuned in to a specific pattern of electrical activity at a specific frequency, then whenever that global activity pattern occurs, those neurons can act as a coordinated assembly". The researchers pointed out that this mechanism of cell assembly formation via oscillatory phase coupling is selective.
While the VEGF-dependent activation of PI3K has been extensively studied, the mechanism of FGF-mediated activation of PI3K has been controversial until few years ago when it was demonstrated that a growth factor-induced coordinated assembly of a multi-docking protein complex is necessary for the FGF-2-mediated activation of PI3K [17].
These results support identification of PfSRP genes in the present study as the real constituents of the P. falciparum SRP machinery and further suggest that PfSRP RNA like its other homologs provides a backbone for the coordinated assembly of PfSRP proteins.
Historically, the IFN-β promoter has been thought to be activated via an enhanceosome, requiring the coordinated assembly of IRFs, NF-κB p65 and p50 subunits and the DNA-bending protein high mobility group protein-1 (HMG-1; Du & Maniatis, 1994; Panne et al, 2007).
Zarnegar, B.J. et al. Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.
An important subclass of these motifs are characterized by a high proline content and play a pivotal role in biological processes requiring the coordinated assembly of multi-protein complexes.
The precise segregation of sister chromatids into daughter cells during mitosis is an essential process that requires the coordinated assembly of multi-protein structures known as kinetochores onto centromeric DNA [1], [2].
