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Replication was built into the fabric of our design: we used a Coordinated Analysis with 15 international datasets, representing 44,094 participants.
This project requires a peculiar data management infrastructure to collect data registered in stations very far from each other and to allow a coordinated analysis.
(The WP29 has also now put out a response statement, in which it notes it will be kicking off initial expert discussions this week — "in order to provide a coordinated analysis of the Court's decision and to determine the consequences on transfers" — with a full meeting of the working party due to be "shortly scheduled").
This became especially relevant when we set out to perform a coordinated analysis of all data from this study.
The authors present a coordinated analysis of transcriptional changes and genome-wide binding of the key transcription factor EIN3 (which accumulates upon ethylene treatment and which is both necessary and sufficient for most ethylene responses) during a time course after addition of ethylene.
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We did not directly examine nonlinear relationships in this feasibility study, but they may contribute to heterogeneity among studies; a more fully coordinated analysis should improve our ability to assess nonlinear relationships.
This kind of data from PROMICS-3 are of a potential value for further coordinated analysis of ISTP events using multipoint observations.
27 31 32 At the statistical level, researchers are encouraged to focus on the analysis of a single study, not the coordinated analysis of multiple data sets with the aim of studying replicability.
A common protocol (available from the authors) for the design and analysis of data from multiple Asian cities and a management framework to conduct the coordinated analysis were established.
Submitting this coordinated analysis of data will demonstrate to regulatory agencies (United States Food and Drug Administration, Therapeutic Goods Administration, Brazilian Health Surveillance Agency, etc).
This coordinated analysis is essential to acquire maximum information including isotopes, texture, and chemistry from micrometer- to nanometer-scale samples.
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