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The phrase "a controlled substance" is correct and usable in written English.
It is typically used in legal, medical, or regulatory contexts to refer to drugs or chemicals that are regulated by law due to their potential for abuse or addiction.
Example: "Possession of a controlled substance without a prescription can lead to serious legal consequences."
Alternatives: "regulated drug" or "restricted substance".
Exact(60)
was a controlled substance analogue..
Too bad it's a controlled substance.
A controlled substance is a controlled substance whether it's cocaine or heroin.
She was charged with criminal possession of a controlled substance.
Whitaker was charged with possession of a controlled substance.
That is why it is a controlled substance.
Ketamine is a controlled substance and can produce mild euphoria.
§ 1311.140 Requirements for signing a controlled substance prescription.
That's one of the reasons they're a controlled substance.
§ 1311.135 Requirements for creating a controlled substance prescription.
Marijuana remains a controlled substance — and illegal — under federal law.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com