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This was a controlled population.
The sensitivity of the method was demonstrated by accurate and consistent readouts from a controlled population of mutant genotypes.
Monozygotic twins discordant for disease represent a controlled population in which to identify potentially disease-associated CNVs.
Here we dissect the relationship between Hsp90 buffering, genetic and non-genetic components of morphological variation, canalization and evolvability in a large set of quantitative traits across a controlled population of flies with well-defined genetic backgrounds.
This is due to the open recruitment which does not allow a controlled population.
Villar and Slutsky [ 3] prospectively reviewed the incidence of ARDS in a controlled population of 703,710 during a 3-year period on the Canary Islands.
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A Cochrane review [ 2] identified only five studies that met review criteria, i.e., studies reporting changes in medically treated fall-related injuries among older people following the implementation of a controlled, population-based intervention (a coordinated program using multi-strategy initiatives).
The necessary evidence of new therapies of clinical interest extends beyond clinical trials in a less controlled population and closer to clinical practice justified since several years the need of conducting observational, noninterventional studies.
In phase II trials, a small set of patients are studied to determine if the candidate compound has efficacy in a small, controlled population and to set the doses that will be used in pivotal phase III trials.
To conclude, performing our study on meta-analysis data would be impossible as detailed information for each individual case tests' results is required in order to train and test the CDSS system; therefore, a rather small but controlled population was preferred.
Women between 29 and 61 years of age (n=44 102) participated in the POBASCAM study, a randomised controlled population-based screening trial evaluating the implementation of hrHPV testing in cervical screening (Bulkmans et al, 2004).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com