The importance of the flavivirus prM protein in affecting the host cell permissibility is only beginning to be explored with a recent demonstration of a S139N substitution in the prM protein as a likely contributor of increased microcephaly occurrences in the ZIKV outbreaks in French Polynesia and the Americas60.
Brain atrophy is probably the biggest contributor of increased risk.
On the other hand, migraine was a contributor to increasing importance of sex life among men and lessening interest in sex among women.
Moreover, they are also in agreement with the more recent "multiple parallel hits" theory including genetic predisposition, intestinal macrobiota and insulin resistance as the major contributors of increased oxidative stress and progressive liver damage [ 10].
Histone deacetylase 4 (Hdac4) that represses the muscle transcription factor myocyte enhancer factor 2 (Mef2), being a contributor of muscle dysfunction [ 25], increased around 3-fold at the 3 time points (0.25-14d).
In 2005, Korea implemented a nationwide breast cancer screening program, which may be a contributor to the increased prevalence of breast cancer cases observed in this country.
33 In addition to neurohormonal activation, inflammation has been considered as a contributor to the increased risk of AF in patients with CKD.
Since 2000s, the emerging D. solani species has been proposed as a contributor to the increased incidence of blackleg and soft rot diseases on potato crop in Europe and the Mediterranean basin [ 4].
The findings showed that 'combined exposure' due to posture and one or both of vibration and MMH, rather than the individual exposure to one of the three factors (WBV, posture, MMH) is the main contributor of the increased prevalence of LBP.
HIV infection predisposes a host to NTM infection and the HIV epidemic has been an important contributor to increased incidence of NTM infections in developed countries [ 5].
