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Therefore, for a continuous marker, we have PAR% = (w – q ue )/ w.
For example, BMI (body mass index) is a continuous marker [ 19]; studies have shown the association between high BMI and esophageal adenocarcinoma risk [ 20- 22].
The area under ROC curve is a measure of the ability of a continuous marker to accurately classify tumor and non-tumor tissue.
At times, decisions are based on clinical criteria that take a continuous marker as baseline, and select one or more cut points to determine whether or not a given patient has a certain status or diagnosis.
Glycated hemoglobin (HbA1c) is a continuous marker of glycemia, and levels >5.7% (39 mmol/mol) are associated with increased risk for developing type 2 diabetes as well as micro- and macrovascular events (1).
In order to use the proliferation metagene as a continuous marker of proliferation, we excluded all genes with a high correlation to the proliferation metagene (correlation >0.5) from the analysis prior to clustering.
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Use of more than one cutpoint is better than having just one, but we believe that full use of the available data mandates a careful analysis that uses the actual continuous marker values (Holländer and Sauerbrei, 2006; Royston and Sauerbrei, 2008).
Urine albumin at concentrations ≥30 mg/g creatinine should be considered as a continuous risk marker for cardiovascular events.
Importantly, availability of individual patient data including exact marker levels would allow data to be reanalysed where cutoff levels were not consistent, and also where continuous marker results were desired but results using a cutoff level were given (or vice versa).
Continuous marker scores were normalised prior to inclusion in the IHC4 model.
On the basis of data from continuous marker methylation analyses in primary breast cancer tissues, the methylation levels of RASSF1A and HIN-1 exhibited a strong correlation to each other (R = 0.502, p < 0.01).
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