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A few have proved susceptible to vaccines, but under attack the rest simply become hardened and infinitely resourceful, forcing a continuous escalation of weaponry.
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Ultimately, nalbuphine would be titrated to effect, as is standard in opioid treatment, and a washout period between doses would counter the intent of titration, hence the continuous escalation from 30 mg to 240 mg in this study.
"While the pre-emptive regulatory measures are likely to help dampen household loan growth, the continuous escalation in household sector debt cannot be reined in unless there is a fundamental change in business strategies of Malaysian banks," MARC wrote in a 2011 report on household borrowing.
The continuous escalation of the technical means of advanced life support associated to the antibacterial and antifungal therapy required by the proven or presumed etiology.
Methods: Patients received oral sunitinib 25 mg/day (with escalation to 37.5 mg/day as tolerated) on a continuous daily dosing schedule and paclitaxel 90 mg/m on days 1, 8, and 15 of each 28-day cycle.
In this Phase I open-label dose-escalation study (CBKM120X1101; NCT01283503), oral buparlisib was administered once daily, on a continuous schedule in 28-day cycles, starting at 25 mg/day.
11 The primary objective of this open-label Phase I dose-escalation study was to determine the MTD of oral buparlisib on a continuous daily schedule in adult Japanese patients with advanced solid tumors.
Transdermal administration provides a continuous delivery of rivastigmine through the skin into the bloodstream, avoiding first pass metabolism and allowing a better dose escalation strategy to improve the treatment outcomes.
A phase I study exploring a continuous twice weekly i.v. administration schedule showed excellent clinical tolerability with no drug-related side effects following a predefined dose escalation schedule (Eskens et al, 2003).
A continuous hum reverberates.
This is a continuous change.
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