Study design: Retrospective analysis of 284 women with intrauterine foetal death (n=137), or foetal abnormalities (n=147), who underwent labour induction with sulprostone in a continuous dose of 1 μg/min intravenously.
Nearly every GP prescribed a continuous dose of prednisolone 30 mg per day.
Diabetic patients received insulin (Insulin Huminsulin Normal; Lilly, Fegersheim, France) intravenously over 60 min with a continuous dose of 6 pmol/kg/min.
The administration of sunitinib was less homogeneous, 49 combinations with a continuous dose of 37.5 mg/day, 11 combinations of 50 mg/day sunitinib on a 4 weeks on/2 weeks off schedule, and 1 patient who received 25 mg/day.
In Figure 2 a,b we show how 13 of our variables change over the course of time for an average cell responding to a continuous dose of cisplatin, C = 20 in the model.
In this study, lenalidomide was started with a continuous dose of 10 mg on day 9 of cycle 1 and rituximab was added weekly (375 mg/m) during the first cycle and then monthly (cycles 3 to 12).
Seventy-six patients with advanced breast cancer were treated with tipifarnib using either a continuous dose of 300 or 400 mg twice daily (n = 41) or an intermittent dose of 300 mg twice daily for 21 days followed by 7 days of rest (n = 35).
When sunitinib is administered at the registered dose, 50 mg daily for 4 weeks followed by a 2-week break, or at a continuous dose of 37.5 mg daily, it is frequently associated with adverse effects that include mucositis, fatigue, diarrhea, hand foot skin reaction, hypothyroidism and cardiac toxicity (Demetri et al, 2006).
Single-cell embryos were injected with 35 pg of human BRAF WT, BRAF Q257R or BRAF G596V mRNA and these embryos were treated from 4 hpf to 4 dpf with a continuous dose of 0.1 or 0.2 μM PD0325901 (Fig. 3C).
