Although seemingly straightforward, the statistical comparison of a continuous variable in a randomized controlled trial that has both a pre- and posttreatment score presents an interesting challenge for trialists.
Evaluation of an algorithm to guide patients with type 1 diabetes treated with continuous subcutaneous insulin infusion on how to respond to real-time continuous glucose levels: a randomized controlled trial.
Yet a large controlled trial of continuous Mg++ infusion did not find conclusive effects on DID or outcome [ 132].
To investigate the central nervous effects of exenatide on the hypothalamus, we performed fMRI on obese, nondiabetic men in a randomized controlled trial during continuous intravenous administration of exenatide or placebo.
24 A randomised controlled trial of continuous glucose monitoring compared with self monitoring of blood glucose to study changes in area under the curve of hypoglycaemia and the rate of severe hypoglycaemia in those people with type 1 diabetes at risk of frequent hypoglycaemia is therefore still needed.
Reference 1. Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial.
Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial.
A recent randomised controlled trial of continuous bright light therapy in ICU [7] failed to find an effect on the incidence of delirium.
One such trial is the Renal EFFECT trial, a randomized controlled trial of intermittent vs continuous sunitinib (Motzer et al, 2012).
Further investigation in the form of a randomized controlled trial, its variations, or continuous large scale registry analyses is warranted for evaluation of this technology.
— Helaine E. Resnick, PhD, MPH Secher et al. The effect of real-time continuous glucose monitoring in pregnant women with diabetes: a randomized controlled trial.
