The phrase "a continuous and substantial" is correct and usable in written English.
It can be used to describe something that is ongoing and significant in amount or degree.
Example: "The project requires a continuous and substantial investment of resources to ensure its success."
Alternatives: "an ongoing and considerable" or "a persistent and significant".
In contrast, poor glycaemic control was associated with a continuous and substantial increase in the cumulative prevalence of confirmed clinical DSPN over 24 years.
However, during the interval between the end of fractionated radiotherapy and the last top up irradiation at day 37, MMC treated tumours showed a continuous and substantial decrease in tumour volume, whereas after radiotherapy alone only minor tumour regressions were observed and average tumour volumes tended to increase again after day 23.
Contrary to the view that he would not win a grant, I will argue that he would receive continuous and substantial funding in the modern scientific world.
Joel Abramson Southbury, Conn., April 5, 2009 To the Editor: Two phenomena provide the context for the serious allegations by George Bisharat of Israeli war crimes in the Gaza war (and of Hamas war crimes for launching rockets against Israeli civilians): Israel's settlement building in the occupied territories, and America's continuous and substantial aid.
He remained a continuous and dazzling comic turn.
A genetic perspective on human adiposity therefore emphasizes two key issues: first, that 'pan-human' thrift manifests as a continuous trait with substantial plasticity (discussed in the following section), and, second, that it is subject to within- and between-population variability.
Linear and mixed effects regressions using biomarker quartiles as the exposure were selected for the main analysis after model diagnostics were applied to regressions using exposures as continuous variables and substantial violations of key model assumptions were identified.
In addition, full-time case managers have more dementia expertise, given their continuous education and substantial caseload, whereas the part-time availability of case managers made them less accessible to informal caregivers or professionals.
These moves can, in some cases, be very significant because steady distributions from endowments have come to account for a rising share of university expenditures and because universities may have inadvertently built in deep expectations for continued and continuous substantial endowment growth.
A significant and substantial number of patients indicated they had no familiarity with transplant, hemodialysis, and continuous ambulatory or automated peritoneal dialysis.
Contrariwise, owing to an extra kinematic constraint, in the condition of plane strain some continuous inelastic deformations and substantial re-orientation of principal strain directions in general have to take place in the softening regime prior to strain localization.
