If a tumor requires the continued expression of the oncogene, the gene or pathway would be a high-priority therapeutic target.
This is a first step to understanding that will be vital to successful bone tissue engineering and regenerative medicine, where continued expression of a desired long-term phenotype is crucial.
Missense mutations or in-frame deletions have been shown to account for the continued expression of a nonfunctioning MMR protein (Peltomaki and Vasen, 1997; Debniak et al, 2000; de Jong et al, 2004); therefore SSCP analysis of all MLH1 and MSH2 exons in 10 patients was undertaken to verify the immunohistochemistry result.
Thus, if preventive treatment was started at adult age with progressive tau pathology but still before the anticipated onset of cognitive decline, cognitive abilities were protected to a certain extent, in spite of the continued expression of toxic TauΔK.
In contrast, the AEF-treated OPCs are maintained in a more immature state, evidenced by the continued expression of nestin and A2B5, the limited expression of CNPase, O4 and GalC, and an immature morphology with more limited extension and branching of processes.
The failure of a normally transient STAT3α activation to be down-regulated by cleavage might allow the continued expression of genes such as Bcl-x L – conferring continued resistance to apoptosis in the mammary epithelium.
The resultant protection of dystrophin-deficient fibres by continued expression of utrophin resulted in a reduction in the level of regeneration taking place in skeletal muscle in mdx mice dosed with SMT C1100.
GFP+ cells transfected with K44A-dyn that reached the top of the CP still expressed the DN construct, assayed by continued expression of the HA-tag (Figure S5G R), but the intensity of staining in these neurons was lower than in cells in the IZ/SVZ (Figure S5Q).
We suggest that continued expression of these molecules, as a consequence of the persistence of antigen 85A, helps to retain the cells in the lungs.
Furthermore, the continued expression of hMeCP2Δ166 protein production identifies a region that possibly contains sites important for the targeting and degradation of hMeCP2 FL transcripts.
