The previous analyses of smooth pursuit learning (and our analysis of VOR-increase learning) all found a consistent, trial-by-trial correlation between spikes in a climbing fiber and the induction of plasticity, consistent with the classic, Marr-Albus-Ito model of cerebellar learning.
For example, if a participant listed their opinion as "against" a topic, a trial in which the sender expressed their opinion as "against" the topic was classed as an opinion- consistent trial, whereas a trial in which the sender expressed their opinion as "for" the topic was classed as an opinion- inconsistent trial.
A surprising finding of the present study was the presence of a consistent association between trial-by-trial RT variability and BOLD signal in white matter regions.
Results that appeared significant at α = 0.05 did not show a consistent pattern across trials.
However, a consistent number of trials (almost all involving drug coated balloons) fell outside the significance boundaries in the late lumen loss analysis (web figs 8 and 9).
Inspection of the data revealed that neither wild-type nor NR1 ΔDG mice were visiting the baited arms in a consistent order across trials.
After a few free-choice sessions with no infusions, rats performed the mix of trials reliably, and expressed a consistent bias on free choice trials but no detectable bias on accumulation trials.
The data included in this meta-analysis might differ slightly from those in previous reports because we treated data in a consistent manner across all trials.
Meta-analysis avoids Simpson's paradox, in which a consistent effect in constituent trials is reversed when results are simply pooled.
The mortality and adverse outcome rates from trials included in this individual patient data meta-analysis might differ slightly from previous reports because we treated data in a consistent manner across all trials.
