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Convention organizers knew Khan would be a powerful speaker, but they had not expected he would be a considerably more potent symbol for the campaign than the other "everyday Americans" invited to the stage — and everyone else who appeared in Philadelphia.
The Y516F mutation causes similar changes in the guanine nucleotide binding and transamidating activity characteristics of the protein as R580A, although the latter mutation is a considerably more potent mutation than the former.
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The Groovy ($14) looks like a benign limeade but is considerably more potent; it's made with shiso-infused vodka and yuzu juice and is topped with a shiso leaf, a member of the mint family that adds a nice lilt to the drink.
Furthermore, in in vitro models of angiogenesis, 2-MeOE2 bisMATE proved to be considerably more potent as an inhibitor of angiogenesis than 2-MeOE2 (Netmal et al, 2004).
Like several other responses of neurons to estrogen (Green et al. 1997; Levin-Allerhand et al. 2002; Yu et al. 2004), PSSD is sensitive to both the 17α and 17β isomers of estradiol, the 17α isomer being considerably more potent as an inducer of CA1 spine synapses (MacLusky et al. 2005), despite the fact that it has very low uterotrophic activity (Lundeen et al. 1997).
Further, a mixture of different estrogenic chemicals was considerably more potent than each of the chemicals when tested individually, suggesting that enhanced effects could occur when fish are exposed simultaneously to various estrogenic chemicals (as is likely to occur in rivers receiving effluent).
Although ETR and RPV have similar cross-resistance profiles, ETR is considerably more potent and has a higher genetic barrier to resistance because the recommended 400-mg daily dosage of ETR is 16-fold higher than the recommended 25-mg daily dosage of RPV.
Prior work from our group showed that the antidepressant MAO inhibitor phenelzine is considerably more potent than tranylcypromine as an LSD1 inhibitor.
Earlier cell proliferation studies have shown that STX243 and STX140 are considerably more potent than 2-MeOE2, with some investigations highlighting a 10-fold difference in activity (Day et al, 2003; Wood et al, 2004; Leese et al, 2005).
In contrast, 2,6- and 3,5-DMA both induced cell death, but exhibited considerable variation in potency, in which the aminophenol metabolites were considerably more potent than the corresponding N-hydroxylamines.
The clozapine metabolite, desmethylclozapine, was considerably more potent than the parent drug, whereas clozapine N-oxide was essentially inactive.
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